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Metabolic changes associated with antiretroviral therapy in HIV-positive patients. Prefeitura de Porto Alegre. Porto Alegre, RS, Brasil. Data on demographic variables, cigarette smoking, diabetes mellitus, cholesterol and triglyceride levels, stage of HIV infection, antiretroviral therapy and HCV coinfection were collected. General linear models procedure for repeated measures was used to test the interaction between HAART and HCV coinfection or protease inhibitor treatment.
Gender, smoking habit, intravenous drug use and age were not significantly associated with cholesterol, triglyceride and glucose changes. The results provide further evidence of the role of HAART for the development of metabolic disturbances. Anti-HIV Agents, adverse effects. Hepatitis C. Lipid Metabolism. Cholesterol, blood. Epidemiologic Studies. Agentes Anti-HIV, efeitos adversos. Hepatite C.
Colesterol, sangue. Agentes Anti VIH, efectos adversos. Colesterol, sangre. Adverse drug reactions are one of the important factors associated with reduced quality of life among HIV-infected patients taking highly active antiretroviral therapy HAART.
Increases in serum triglycerides, low-density lipoproteins LDL , and total cholesterol have been reported as well as the development of insulin resistance.
It has been reported that ritonavir increases the production of very low-density lipoprotein cholesterol VLDL , triglycerides, and apolipoprotein apo B in HIV-negative subjects indicating that treatment with this protease inhibitor in the absence of HIV infection can cause dyslipidemia. Of all subjects, we selected all subjects with at least one follow-up lipid profile between January and March Data for hepatitis C virus HCV and tuberculosis coinfection were identified by laboratory testing.